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Nanotechnology Innovation Center of Kansas State

Santosh Aryal

Santosh AryalAssistant Professor


B.S. Chemistry and Biology, Tribhuvan University, Nepal
M. S. Organic Chemistry, Tribhuvan University, Nepal
Ph. D. Bionanosystem Engineering, Chonbuk National University, South Korea




Synthesis and characterization of inorganic/organic nanomaterials; Polymer synthesis and characterization; Polymer-drug conjugates; Combinatorial chemotherapy; Functionalization and surface modification of nanoparticles; PET-CT and MR imaging; Evaluation of nanoparticle using in-vitro and in-vivo models.


Aryal S, Nguyen TD, Pitchaimani A, Shrestha TB, Biller D, Troyer DL. Membrane fusion mediated gold nano-plating of red blood cell: a bioengineered CT-contrast agent. ACS Biomaterials Science and Engineering 3, 36-41, 2017.

DeLong RK, Mitchell JA, Morris RT, Comer J, Hurst MN, Ghosh K, Wanekaya A, Mudge M, Schaeffer A, Washington LL, Risor-Marhanka A, Thomas S, Marroquin S, Lekey A, Smith JJ, Garrad R, Aryal S, Abdelhakiem M, Glaspell GP. Enzyme and cancer cell selectivity of nanoparticles: inhibition of 3-d metastatic phenotype and experimental melanoma by zinc oxide” J Biomed Nanotechnol 13, 221-231, 2017.

Aryal S, Stigliano C, Key J, Ramirez M, Anderson J, Karmonik C, Fung S, Decuzzi P. Paramagnetic Gd3+ labeled red blood cells for magnetic resonance angiography. Biomaterials 98, 163-170, 2016.

Delong RK, Hurst MN, Aryal S, Inchun NK. Unique Boron Carbide Nanoparticle Nanobio Interface: Effects on Protein-RNA Interactions and 3-D Spheroid Metastatic Phenotype. Anticancer Research 36(5): 2097-103, 2016.

Pitchaimani A, Ngugyen T, Wang H, Bossman SH, Aryal S. Design and characterization of gadolinium infused theranostic liposomes. Royal Society of Chemistry Advances  6: 36898-36905, 2016.

Aryal S., Key J., Stigliano C., Landis M. D., Lee D. Y., Decuzzi P. Positron emitting magnetic nanoconstruct for PET/MR imaging. Small (2014) 10, 2688.

Aryal S., Hu, C. M., Fang, R., Dehaini, D., Carpenter, C., Zhang, D. E., Zhang, L. Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release. Nanomedicine (2013), 8, 1271.

Aryal S., Hu C. M., Zhang L. Synthesis of Ptsome: a platinum-based liposome-like nanostructure. Chemical Communication. (2012) 48, 2630.

Hu C. M., Zhang L., Aryal S., Cheung C., Fang R., Zhang L. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proceedings of the National Academy of Science (PNAS) (2011) 108, 10980.

Aryal S., Hu C. M., Zhang L. Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery. ACS Nano (2010) 4, 251.