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Nanotechnology Innovation Center of Kansas State

Dr Masaaki Tamura

tamura2Associate Professor

Degrees

D.V.M., Kitasato University, Japan

Ph.D., Nutrition and Biochemistry, Azabu University

Contact

785-532-4825

mtamura@vet.k-state.edu

Research

My laboratory focuses on the therapeutic applications of nanoparticle-based gene therapy, hyaluronan-cisplatin nanoparticle chemotherapy, the angiotensin II type 2 receptor (AT2R), and umbilical cord matrix stem cells for multiple organ type cancers.  

Major Equipment

Fluorescent microscope equipped with CO2 incubator with computer imaging; microscope equipped with computer image analysis capability.

Publications

Uppalapati, L., Ohta, N., Zhang, Y., Kawabata, A., Pyle, M., Becker, K. G., Troyer, D., and Tamura, M.: Screening and characterization of unique tumoricidal genes in rat umbilical cord matrix stem cells. Mol Pharmaceutics 8:1549-1558, 2011. 

Kawabata, A., Matsuzuka, T., Doi, C., Seiler, G., Reischman, J., Pickel, L., Ayuzawa, R., Nguyen, T., and Tamura, M.: C1B domain peptide of protein kinase C significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis. Cancer Biol. Ther. 13. 2012. 

Basel, M., Balivada, S., Shrestha, T., Seo, G-M., Myers, C., Pyle, M., Tamura, M., Bossmann, S., Troyer, D.:  A Cell-Delivered and -Activated SN38-Dextran Prodrug Increases Survival in a Murine Disseminated Pancreatic Cancer Model. Small, 8:913-920, 2012. PMID:22238072

Basel, M., Balivada, S., Wang, H., Shrestha, T., Seo, G-M., Pyle, M., Abayaweera, G., Dani, R., Koper, O., Tamura, M., Chikan, V., Bossmann, S., Troyer, D.: Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model. Int. J. Nanomed. 7:297-306, 2012. PMID:22238072

Kawabata, A., Baoum, A., Ohta, N., Jacquez, S., Seo, G. M., Berkland, C. and Tamura, M.: Intratracheal administration of a nanoparticle-based therapy with the angiotensin II type 2 receptor gene attenuates lung cancer growth. Cancer Res, 72:2057-67,2012, Epub 2012 Mar 2. PMID:22238072

Kawabata, A., Matsuzuka, T., Doi, C., Seiler, G., Reischman, J., Pickel, L., Ayuzawa, R., Nguyen, T., and Tamura, M.: C1B domain peptide of protein kinase C significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis. Cancer Biol. Ther. 13:880-889,2012. PMID:22785210,PMCID:PMC3414411

Kawabata, A., Ohta, N., Seiler, G., Pyle, M., Ishiguro, S., Zhang, Y., Becker, K. G., and Tamura, M.: Naïve rat umbilical cord matrix stem cells significantly attenuates mammary tumor growth through modulation of an endogenous immune responses to the tumors. Cytotherapy, 15:586-597, 2013. PMID:23474329, PMCID:PMC3652627

Magnani, F., Pappas, C.G., Crook, T., Magafa, V., Cordopatis, P., Ishiguro, S., Ohta, N., Selent, J., Bosnyak, S., Jones, E. S., Gerothanassis, I. P., Tamura, M., Widdop, R. E., Tzakos, A. G.: Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II. ACS Chem Biol, 2014. May 14. [Epub ahead of print] PMID: 24787922

Ishiguro, S., Yoshimura, K., Takao, S., Kawabata, A., Wall, T., Tsunedomi, T., Oka, M., Inui, M., Pappas, C., Tzakos, A.G., and Tamura, M., Involvement of an angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice. Cancer Biol Ther, 16:308-17, 2015. PMID: 25756513

Ohta, N., Ishiguro, S., Kawabata, A., Uppalapati, L., Ball, J., Pyle, M., Troyer, D., De, S., Zhang, Y., Becker, K., andTamura, M.: Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes. PLoS One,10:e0123756, 2015. PMID: 25942583, PMCID: PMC4420498

Alhakamy, N*. A., Ishiguro, S.*, Uppalapati, D., Berkland, C. J., and Tamura, M.: AT2R gene delivered by condensed polylysine complexes attenuates lewis lung carcinoma after intravenous injection or intratracheal spray. Mol Cancer Ther, 2015 Dec 4. pii: molcanther.0448.2015. [Epub ahead of print] PMID: 26637367, *, Co-first authors. 

Books & Chapters

Ohta, N., Kawabata, A., Uppalapati, D., Ishiguro, S., Troyer, D., and Tamura, M.: Cytotherapy for breast cancer by umbilical cord matrix stem cells. Stem Cell Therapeutics for Cancer, Editor: Khalid Shah, Wiley publisher,pp111-126, 2013 Print ISBN: 9781118282427, Online ISBN: 9781118660423

 

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