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Nanotechnology Innovation Center of Kansas State

Santosh Aryal

Santosh AryalAssistant Professor


B.S. Chemistry and Biology, Tribhuvan University, Nepal
M. S. Organic Chemistry, Tribhuvan University, Nepal
Ph. D. Bionanosystem Engineering, Chonbuk National University, South Korea




Synthesis and characterization of inorganic/organic nanomaterials; Polymer synthesis and characterization; Polymer-drug conjugates; Combinatorial chemotherapy; Functionalization and surface modification of nanoparticles; PET-CT and MR imaging; Evaluation of nanoparticle using in-vitro and in-vivo models.

Chemistry department web page: http://www.k-state.edu/chem/people/grad-faculty/aryal/lab/index.html

Google Scholars Page


Drug Delivery Nanoparticles with Locally Tunable Toxicity Made Entirely from a Light-Activatable Prodrug of Doxorubicin
C Schutt, S Ibsen, E Zahavy, S Aryal, S Kuo, S Esener, M Berns, S Esener
Pharmaceutical research 34 (10), 2025-2035
Interaction of Immune System Protein with PEGylated and Un-PEGylated Polymeric Nanoparticles
M Eshete, K Bailey, TDT Nguyen, S Aryal, SO Choi
Advances in Nanoparticles 6 (03), 103
Impact of cell adhesion and migration on nanoparticle uptake and cellular toxicity
A Pitchaimani, TDT Nguyen, M Koirala, Y Zhang, S Aryal
Toxicology in Vitro
Elucidating the RNA Nano-bio Interface: Mechanisms of Anti-Cancer Poly I: C RNA and Zinc Oxide Nanoparticle Interaction
M Ramani, TDT Nguyen, S Aryal, KC Ghosh, RK DeLong
The Journal of Physical Chemistry C
Gd3+ Tethered Gold Nanorods for Combined Magnetic Resonance Imaging and Photo-Thermal Therapy
A Pitchaimani, TDT Nguyen, L Maurmann, J Key, SH Bossmann, S Aryal
Journal of Biomedical Nanotechnology 13 (4), 417-426
Methotraxate‐Loaded Hybrid Nanoconstructs Target Vascular Lesions and Inhibit Atherosclerosis Progression in ApoE−/− Mice
C Stigliano, MR Ramirez, JV Singh, S Aryal, J Key, E Blanco, P Decuzzi
Advanced Healthcare Materials
Enzyme and Cancer Cell Selectivity of Nanoparticles: Inhibition of 3-D Metastatic Phenotype and Experimental Melanoma by Zinc Oxide
RK DeLong, JA Mitchell, RT Morris, J Comer, MN Hurst, K Ghosh, ...
Journal of Biomedical Nanotechnology 13 (2), 221-231
A review on nanoparticle-based technologies for biodetoxification
M Faqir, NDT Tuyen, R Ahmad, A Bushra, A Santosh
Drug and Chemical toxicology, 1-9
Membrane fusion mediated gold nano-plating of red blood cell: a bioengineered CT-contrast agent
S Aryal, TDT Nguyen, A Pitchaimani, TB Shrestha, D Biller, DL Troyer
ACS Biomaterials Science & Engineering 3 (1), 36-41
Engineered Nanomedicine with Alendronic Acid Corona Improves Targeting to Osteosarcoma
TDT Nguyen, P Arunkumar, AryalSantosh
Scientific Reports 6, 36707
Paramagnetic Gd 3+ labeled red blood cells for magnetic resonance angiography
S Aryal, C Stigliano, J Key, M Ramirez, J Anderson, C Karmonik, S Fung, ...
Biomaterials 98, 163-170
Unique boron carbide nanoparticle nanobio interface: effects on protein-RNA interactions and 3-D spheroid metastatic phenotype
RK Delong, MN Hurst, S Aryal, NK Inchun
Anticancer research 36 (5), 2097-2103
Polymeric Nanomedicine for Targeting Bone Microenvironment
TDT Nguyen, SS Sridibhatla, A Pitchaimani, S Aryal
한국고분자학회 학술대회 연구논문 초록집, 45-45
Design and characterization of gadolinium infused theranostic liposomes
A Pitchaimani, TDT Nguyen, H Wang, SH Bossmann, S Aryal
RSC Advances 6 (43), 36898-36905
Engineered biomimetic nanoabsorbent for cellular detoxification of chemotherapeutics
TDT Nguyen, A Pitchaimani, MB Koirala, F Muhammad, S Aryal
RSC Advances 6 (39), 33003-33008
Synthesis and characterization of biomimetic hydroxyapatite nanoconstruct using chemical gradient across lipid bilayer
MB Koirala, TDT Nguyen, A Pitchaimani, SO Choi, S Aryal
ACS applied materials & interfaces 7 (49), 27382-27390
Soft Discoidal Polymeric Nanoconstructs Resist Macrophage Uptake and Enhance Vascular Targeting in Tumors
K Jaehong, P Anna Lisa, G Francesco, S Aryal, S Cinzia, DM Daniele, ...
ACS Nano
Radiolabeled polymeric nanoconstructs loaded with docetaxel and curcumin for cancer combinatorial therapy and nuclear imaging
C Stigliano, J Key, M Ramirez, S Aryal, P Decuzzi
Advanced Functional Materials 25 (22), 3371-3379
Opportunities for nanotheranosis in lung cancer and pulmonary metastasis
J Key, YS Kim, F Tatulli, AL Palange, B O’Neill, S Aryal, M Ramirez, X Liu, ...
Clinical and translational imaging 2 (5), 427-437
Synthesis of multifunctional magnetic nanoflakes for magnetic resonance imaging, hyperthermia, and targeting.
A Cervadoro, M Cho, J Key, C Cooper, C Stigliano, S Aryal, A Brazdeikis, ...
ACS applied materials & interfaces 6 (15), 12939