Kansas State University

Tuyen Nguyen, graduate student of Dr. Santosh Aryal, received 1st place award ($500.00) “Tiny superhero fights against cancer” from the Graduate School for her 3 min competition at the 2nd Annual 3 MT Thesis Competition and the People’s Choice award ($125.00) on 2/16/17. 

Dr. Nancy Monteiro-Riviere was selected in March 2016 as an “Eminent Toxicologist” because of her major contribution to the science of toxicology and engaging ability as a public speaker. Her lecture on “Frontiers in Nanotoxicology of the Skin” was videotaped and archived in the Eminent Toxicologist Series to incorporate prominent toxicologists who have created history.  

“Frontiers in Nanotoxicology of the Skin” (Recording)
“Frontiers in Nanotoxicology of the Skin” (Slides)

Dr. Ran Chen, Postdoctoral fellow of Dr. Jim Riviere received the Outstanding Poster Award on his research entitled “Biological surface adsorption index: environmental applications and parallel molecular dynamics simulation”.

Dr. Parwathy Chandran, Postdoctoral fellow of Dr. Nancy Monteiro-Riviere was selected for an oral presentation on “Role of physicochemical properties of gold nanoparticles on biocorona formation and cellular uptake profiles in endothelial cells”.

Dr. Abhilash Sasidharan, Postdoctoral fellow of Dr. Nancy Monteiro-Riviere received a Travel Award to attend the Congress based on his abstract “Understanding the impact of biocorona on the interaction of gold nanoparticles with human blood components.

Dr. Yang Li, Postdoctoral fellow of Dr. Nancy Monteiro-Riviere received a Travel Award to attend the Congress based on his abstract “Cellular uptake mechanisms of gold nanoparticles with three different coatings and protein corona effects on cell uptake in human keratinocytes”.  

Dr. Kyoungju Choi, Research Assistant Professor in Dr Nancy Monteiro-Riviere’s laboratory gave a presentation on “In vitro assessment of size, surface chemistry and protein corona effects on hepatic uptake and toxicity of gold nanoparticles in human hepatic cells.  

Dr. Zhoumeng Lin gave an oral presentation on “PBPK modeling of gold nanoparticles: a tool to extrapolate from animals to man”. 

Dr. Jim Riviere organized and Chaired the “Physiological based pharmacokinetic modeling of nanomaterials” session and gave a presentation on the Physiological based pharmacokinetic modeling of nanomaterials: why is quantitation and anatomical /physiological reality so important?

Dr. Nancy Monteiro-Riviere served on the International Organization Advisory Board for the International Nanotoxicology Congress, the Abstract Review Committee, and served on the Panel Discussion Member for the Opening Ceremony and Chaired the Biomolecular Corona Session.

Oldenburg S, Hunt P, Hussain SM, Monteiro-Riviere NA. Searching for risk, finding value: unexpected developments from nanotoxicology/industry collaborations. The 8^th International Nanotoxicology Congress, p. 377, #59, 2016.

Brown J, Monteiro-Riviere NA. Impact of the biomolecular corona on nanoparticle uptake and cellular response. The 8^th International Nanotoxicology Congress. p. 28, 2016.

Honors and Awards: 

1. Dr. Nancy Monteiro-Riviere was selected as an “Eminent Toxicologist” because of her major contribution to the science of toxicology and engaging ability as a public speaker. Her lecture on “Frontiers in Nanotoxicology of the Skin” was videotaped and archived in the Eminent Toxicologist Series to incorporate prominent toxicologists who have created history.  
2. Dr. KuKanich served on the KSU’s Mentoring Fellowship program for Dr. Eshar on the grant: “Pharmacokinetics of one antibiotic drug (enrofloxacin) and one analgesic/anti-inflammatory drug (meloxicam) in zoo-kept black-tailed prairie dogs”.
3. Dr. Aryal, Graduate Student Summer Stipend for $ 4807.00 for T.Nguyen. Ms. Nguyen received the Phi Lambda Upsilon award.
4. Dr. A. Pitchaimani, a postdoctoral fellow under Dr. Aryal received a $1000 travel award.
5. Dr. Nancy Monteiro-Riviere was Chairperson of the Alternative In Vitro Toxicity Models Session at The 55^th Annual Meeting of the National Society of Toxicology, New Orleans, LA. March 16, 2016.
6. Dr. Parwathy Chandran, a postdoctoral fellow under Dr. Nancy Monteiro-Riviere received the Outstanding Postdoctoral Award at the Nanotoxicology Specialty Section at the 55^th National Society of Toxicology, New Orleans, LA, March16, 2016.
7. Drs. Lin, Monteiro-Riviere NA, Riviere JE received an Honorable Mention for best paper from the Biological Modeling Specialty Section of the National Society of Toxicology entitled “A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice”. Nanotoxicology 10(2):162-172, 2016.
8. Drs. Lin, Monteiro-Riviere NA, Riviere JE publication “Pharmacokinetics of metallic nanoparticles” in WIREs Nanomedicine and Nanobiotechnology, 7(2):189-217, 2015 was listed in the Top Ten most accessed paper.
9. Dr. Nancy Monteiro-Riviere was Chair of the National Institute of Environmental Health Sciences (NIEHS) Special Emphasis Panel on Engineered Nanomaterials Grant Applications UO1. April, 2016.
10. Dr. Jim Riviere completed a year-long critical review of the USDA/FSIS National Residue Program for Meat, Poultry and Egg Products (2014-2015) released by the Pew Charitable Trusts on March 8, 2016.
11. Patrick Guvele, an undergraduate student working in Dr. Monteiro-Riviere’s lab at the NICKS Center, received an Honorable Mention at the 16^th Annual Developing Scholars Program Research Symposium at KSU on April 17, 2016. 

Book Chapters: 

1. Samberg ME, Lin Z, Monteiro-Riviere NA. In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles. In Encyclopedia of Nanotechnology (Ed. Bhushan, B.). Springer Science and Business Media, Dordrecht, pp.1-14, 2015. DOI: 10.1007/978-94-007-6178-0_331-2 

2. Narayan RJ, Boehm RD, Monteiro-Riviere NA. Cell and Protein Interactions with Diamond.  In  Handbook of Clinical Medicine-Law, Business, Regulation, Safety and Risk, (Eds. Bawa R, Audette G, Reese BE), Vol.11, Section III-Health, Safety, Risk and Biological Interactions, Pan Stafford Publishing, Singapore, Chapter 33, pp.809-822, 2016.
3. Monteiro-Riviere NA. Safety of Nanoparticle Skin Penetration. In Percutaneous Penetration Enhancers-Chemical Methods in Penetration Enhancement-Nanocarriers Series (Eds. Dragicevic N and Maibach HI), Springer-Verlag Publishers, Heidelberg, Germany, Vol. 2, Chapter 24, pp. 363-376, 2016.

Abstracts: 

1. Choi K, Koci J, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Mechanistic toxicity assessment of hexahydroisohumulone incanine hepatocytes, renal proximal tubules, and enterocyte like-cells.  The Toxicologist 150, p.487, #3078, 2016. 
2. Monteiro-Riviere NA, Ortega MT, Koci J, Lin Z, Jeffery B, Riviere JE. Comparative in vitro cytotoxicity of 20 potential food ingredients in canine liver, kidney, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. The Toxicologist 150, p.487-488, #3079, 2016.
3. Sasidharan A, Monteiro-Riviere NA. Impact of the protein corona on the blood compatibility profile of gold nanoparticles. The Toxicologist 150, p.415, #2766, 2016.
4. Chandran P, Monteiro-Riviere NA. The effect of protein corona formation on the intracellular uptake profiles of gold nanoparticles in human primary vascular endothelial cells. The Toxicologist 150, p.413-414, #2760, 2016.
5. Zhang LO, Li J, He X, Lv X, Chen D, Li L, Chen C, Zhao Y, Wang F, Monteiro-Riviere NA, Guo Z. Mitochondria-targeted platinum coordination compounds may increase cell adhesion and inhibit migration. The Toxicologist 150, p.154, #1656, 2016.
6. Lin Z, Monteiro-Riviere NA, Kannan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles. The Toxicologist 150, p.117, #1504, 2016.
7. Muhammad F, Jaberi-Douraki M, de Souza D, Riviere JE. modulation of chemical dermal absorption by 14 natural products: a quantitative structure permeation (QSPR) analysis of components often found in topical cosmeceuticals. The Toxicologist 150, p. 590, #3512, 2016.
8. Nguyen T, Pitchaimani A, Koirala M, Aryal S. Engineering Biomimetic Nanoabsorbent for Detoxification of Chemotherapeutics. Capitol Graduate Research Summit, Topeka, KS, February 2, 2016.
9. Sridibhatla S, Nguyen T, Pitchaimani A, Koirala M, Aryal S. Bisphosphonate functionalized nanomedicine for targeting bone microenvironment. Capitol Graduate Research Summit, Topeka, KS, February 2, 2016.
10. Nguyen T, Pitchaimani A, Wang H, Bossmann S, Aryal S. Bone microenvironment targeted magnetic nanomedicine.  K-State Graduate Research, Arts, and Discovery(GRAD) Forum, KSU,    Manhattan, KS, March 2016.     
11. Inchun N, Curtis C, Thomas S, Marroquin S, Hurst M, DeLong RK. Characterization of the interactions between model RNA, protein, and bio-relevant nanoparticles. ERN-Emerging Researchers National Conference in STEM, Washington, DC, 274:A239, 2016.
12. Ramani M and DeLong RK.Absorption mechanisms of poly I: c RNA onto zinc oxide   nanoparticles:maximizing the payload. Experimental Biology 823.4: 261, 2016.
13. Thomas S, Marroquin S, DeLong RK. Elucidating the dynamics of nanoparticle-protein interaction at a biomolecular level: structural and functional studies using firefly luciferase.  Experimental Biology  969.34: 323, 2016.
14. Wang H, Chen R, Chen L, Qiu P, Xu J, Huang E, Liu C, Lin Z, Xie W. DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. The Toxicologist, 150, p. 433, #2843, 2016.
15. Xie W, Cai D, Qiao D, Yue X, Wang Q, Li D, Lin Z, Wang H. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. The Toxicologist, 150, p. 78, #1329, 2016.

Invited Presentations: 

1.   Dr. Aryal “Rational Design of Polymeric Nanoparticle as a Theranostic Device”, Chonbuk National University, Jeonju, South Korea, April 2, 2016.

2.   Dr. Aryal “Polymeric Nanomedicine as a Therapeutic and Diagnostic Modality”, Yonsei University, Wonju, South Korea, April 4, 2016.

3.   Dr. Aryal “Polymeric Nanomedicine for Targeting Bone Microenvironment”, Polymer Society of Korea, Daejeon, South Korea, April 8, 2016.

The following Abstracts were presented: 

1. Choi K, Koci J, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Mechanistic toxicity assessment of hexahydroisohumulone incanine hepatocytes, renal proximal tubules, and enterocyte like-cells.  The Toxicologist 150, p.487, #3078, 2016. 
2. Monteiro-Riviere NA, Ortega MT, Koci J, Lin Z, Jeffery B, Riviere JE. Comparative in vitro cytotoxicity of 20 potential food ingredients in canine liver, kidney, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. The Toxicologist 150, p.487-488, #3079, 2016.
3. Sasidharan A, Monteiro-Riviere NA. Impact of the protein corona on the blood compatibility profile of gold nanoparticles. The Toxicologist 150, p.415, #2766, 2016.
4. Chandran P, Monteiro-Riviere NA. The effect of protein corona formation on the intracellular uptake profiles of gold nanoparticles in human primary vascular endothelial cells. The Toxicologist 150, p.413-414, #2760, 2016.
5. Zhang LO, Li J, He X, Lv X, Chen D, Li L, Chen C, Zhao Y, Wang F, Monteiro-Riviere NA, Guo Z. Mitochondria-targeted platinum coordination compounds may increase cell adhesion and inhibit migration. The Toxicologist 150, p.154, #1656, 2016.
6. Lin Z, Monteiro-Riviere NA, Kannan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles. The Toxicologist 150, p.117, #1504, 2016.
7. Muhammad F, Jaberi-Douraki M, de Souza D, Riviere JE. modulation of chemical dermal absorption by 14 natural products: a quantitative structure permeation (QSPR) analysis of components often found in topical cosmeceuticals. The Toxicologist 150, p. 590, #3512, 2016. 

The following Honors and Awards were received: 

1. Dr. Nancy Monteiro-Riviere was selected as an “Eminent Toxicologist” because of her major contribution to the science of toxicology and engaging ability as a public speaker. Her lecture on “Frontiers in Nanotoxicology of the Skin” was videotaped and archived in the Eminent Toxicologist Series to incorporate prominent toxicologists who have created history.  
2. Dr. Nancy Monteiro-Riviere was Chairperson of the Alternative In Vitro Toxicity Models Session at The 55^th Annual Meeting of the National Society of Toxicology, New Orleans, LA. March 16, 2016.
3. Dr. Parwathy Chandran, a postdoctoral fellow under Dr. Nancy Monteiro-Riviere received the Outstanding Postdoctoral Award at the Nanotoxicology Specialty Section at the 55^th National Society of Toxicology, New Orleans, LA, March16, 2016.
4. Drs. Lin, Monteiro-Riviere NA, Riviere JE received an Honorable Mention for best paper from the Biological Modeling Specialty Section of the National Society of Toxicology entitled “A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice”. Nanotoxicology 10(2):162-172, 2016.
5. Drs. Lin, Monteiro-Riviere NA, Riviere JE publication “Pharmacokinetics of metallic nanoparticles” in WIREs Nanomedicine and Nanobiotechnology, 7(2):189-217, 2015 was listed in the Top Ten most accessed paper.

The Sept. 15 issue of The Journal of Physiology highlights Peying Fong and Jeffrey Comer from the College of Veterinary Medicine's anatomy and physiology department for their independent contributions on the featured topic of CLC — or chloride channel — transport proteins.

Sasidharan S, Riviere JE, Monteiro-Riviere NA. Impact and implications of gold nanoparticle interactions with human serum proteins and biocorona formation. Central States Society of Toxicology, p.19, #03, 2014. Received best postdoctoral oral presentation and received a travel award to the National Society of Toxicology meeting in San Diego, CA, March, 2015.

Choi K, Riviere JE, Monteiro-Riviere NA. Safety assessment of pet food ingredients using cryopreserved canine hepatocytes-based in vitro assays.  The Toxicologist 144, p. 20, #102, 2015.

Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Toxicological effect of a pet food ingredient on canine bone marrow derived mesenchymal stem cells and enterocyte-like cells. The Toxicologist 144, p. 85, #400, 2015.

Sasidharan S, Riviere JE, Monteiro-Riviere NA. Impact and implications of gold nanoparticle interactions with human serum proteins and biocorona formation. The Toxicologist 144, p. 64, #298, 2015. (Awarded 2nd place for best poster)

Lin Z, Monteiro-Riviere NA, Riviere JE. Prediction and comparison of size-dependent biodistribution of polyethylene glycol-coated gold nanoparticles in adult mice: a physiologically based pharmacokinetic model. The Toxicologist 144, p. 65, #305, 2015.

Koci J, Jeffery B, Riviere JE, Monteiro-Riviere NA. Canine renal proximal tubule cells as an in vitro model for toxicity assessment of pet food ingredients. The Toxicologist 144, p. 490, #2280, 2015.

Zhang LW, Monteiro-Riviere NA, Li J, Yang L. Nanoparticles exacerbate drug induced phospholipidosis. The Toxicologist 144, p. 416, #1942, 2015.

NICKS Announces four KSU Faculty

Dr. Jeffrey Comer comes to KSU from a postdoctoral position at the CNRS at the University de Lorraine in France. His research interests is molecular modeling at the interface of biology and nanotechnology. He holds a PhD in Physics from the University of Illinois. Click for seminar video

Dr. Seong-O Choi was a research engineer at the Georgia Institute of Technology in Atlanta. His research focus is on applying nanotechnology to applications in transdermal and intracellular drug delivery. He holds a PhD in Electrical and Computer Engineering from Georgia Institute of Technology. Click for seminar video

Dr. Santosh Aryal comes to KSU from the Department of Translation Imaging at the Houston Methodist Research Institute (HMRI) in Houston, TX. His research is focused on synthesis, characterization, and biomedical evaluation theranostics nanobiomaterials for cancer therapy and diagnosis. He holds a PhD in Bionanosystem Engineering from Chonbuk National University in South Korea. click for seminar video

Dr. Robert DeLong comes to KSU from Missouri State University in Springfield, Missouri. His research is focused on particle based delivery of DNA, RNA and vaccines against cancer and infectious disease. He holds a PhD in Biochemistry and Biophysics from The Johns Hopkins University in Baltimore, Maryland. click for seminar video

Controlled Release Society Interview with Dr. Monteiro-Riviere

CRS- Controlled Release Society Newsletter; Nanotechnology- Interview-Vol. 31, (2), pp.8-11, 2014. Read More at controlled release society

Dr. Nancy Monteiro-Riviere’s lab presented their research at The 53^rd Annual Meeting of the National Society of Toxicology, March 25, 2014, Phoenix, Arizona

1. Koci J, Jeffery B, Riviere JE, Monteiro-Riviere NA. In vitro safety assessment of pet food ingredients on canine proximal tubule cells. The Toxicologist 138, p.81, #320, 2014.
2. Williams FM, Ambrosio M, Barrett G, Cronin MT, Guy RH, Plautz JR, Monteiro-Riviere NA, Roper C, Rothe H, Rua D, Verwei M, Yang C. Threshold of toxicological concern (TTC): A strategy to support application of TTC to dermally applied cosmetic ingredients. The Toxicologist 138, p. 168, #632, 2014.
3. Riviere JE, Sahneh FD, Scoglio C, Monteiro-Riviere NA. A pharmacokinetic modeling framework for interspecies extrapolations of nanoparticle biodistribution taking into account biocoronas dynamics independent of species-specific disposition processes. The Toxicologist 138, p.211, #818, 2014.
4. Sasidharan A, Chen R, Oldenburg S, Riviere JE, Monteiro-Riviere NA. Understanding the dynamic behavior of the protein corona and its influence on the physicochemical composition of silver nanoparticles. The Toxicologist 138, p.211-212, #819, 2014.
5. Monteiro-Riviere NA, Zhang LW, Veronesi B. Toxicity assessment of six titanium dioxide nanoparticles in human epidermal keratinocytes. The Toxicologist 138, p.212, #820, 2014.
6. Zhang LW, Jeffery B, Riviere JE, Monteiro-Riviere NA. Safety assessment of potential food ingredients on canine primary hepatocytes. The Toxicologist 138, p.420, #1616, 2014.

*Dr. Nancy Monteiro-Riviere Chaired the Nanotoxicology: Metals, Environmental, and In Silico Session at The 53^rd Annual Meeting of the National Society of Toxicology, March 25, 2014

Invited presentation to The Risk Assessment Bureau, Consumer Product Safety Directorate of Health Canada, Ottawa, Canada. 

Dr. Monteiro-Riviere -- “How The Physicochemical Properties of Nanoparticles May Influence Skin Penetration and Toxicity for Risk Assessment Analysis” on February 21, 2014.

*Dr. Nancy Monteiro-Riviere’s new book the second edition of “Nanotoxicology: Progress Toward Nanomedicine“ has been released.

http://www.crcpress.com/product/isbn/9781482203875

• Explores the biological interactions of nanomaterials with biological systems

• Reviews latest advances in nanotoxicology and nanomedicine with detection methods and advanced methodologies for assessing nanomaterials 

• Discusses exposure, modeling, methodologies and techniques, hazards, and risk assessment applicable to occupational and health, nanomedicine, the environment, and life sciences 

• Examines hazards of nanomaterials to the dermal, respiratory, immune, cardiovascular, neuro, and reproductive systems, along with interspecies comparisons and genotoxicity issues 

• Includes all new sections on cell–based targeting and biomedical applications and nanofabrication for medical devices 

• Outlines risk assessment of nanomaterials